When analyzing subtypes of hematological malignancy, we observed an inverse association of HDL-C with acute myeloid leukemia (HR 0.86; 95% CI 0.75–0.97), of TC (HR 0.89; 95% CI 0.84–0.94) and LDL-C (HR 0.90; 95% CI 0.83–0.98) with multiple myeloma, and of TC (HR 0.95; 95% CI 0.92–0.98), TG (HR 0.96; 95% CI 0.93–0.997) and ApoA-I (HR 0.93; 95% CI 0.88–0.99) with non-Hodgkin lymphoma. Here, APOA1 is linked to acute myeloid leukemia.