We observed a decreased risk of hematological malignancy associated with one SD increase of TC (HR 0.93; 95% CI 0.91–0.96), LDL-C (HR 0.94; 95% CI 0.91–0.97), HDL-C (HR 0.92; 95% CI 0.86–0.99), and ApoA-I (HR 0.96; 95% CI 0.93–0.996). Here, APOA1 is linked to hematologic disorder.