In this case, SC-derived CXCL5 by binding to its receptor CXCR2 in tumour cells activates PI3K/Akt/GSK-3β signalling, increasing the expression of the EMT-TFs Snail1 and Twist1 in these cells [187] and also in hepatocellular carcinoma cells [191]. This evidence concerns the gene TWIST1 and neoplasm.