Furthermore, EMT-TFs such as Zeb1 and Twist1, which are known to promote invasion and ECM changes, are present in mesenchymal-like melanoma cells [126] and play roles similar to those in EMT: they suppress E-cadherin, drive dedifferentiation and correlate with lower metastasis-free and recurrence-free survival rates [128,133]. Here, TWIST1 is linked to melanoma.