Multiple treatments are used for the management of HF and other cardiac diseases including mineralocorticoid receptor antagonists (MRA), loop diuretics and angiotensin pathway targeted: angiotensin II receptor blockers (ARB), dual angiotensin receptor and neprilysin inhibitors (ARNi), and angiotensin-converting enzyme (ACE) inhibitors. The gene discussed is ACE; the disease is hydrops fetalis.