There is an increasing amount of evidence supporting the role in neurodegenerative diseases of lysosomes,83 which play an important role in phagocytic cells, including microglia.84 Our analysis identified three known (GRN, TMEM106B and CTSH) and one novel (CLN5) AD-associated loci related to lysosomal functions. Here, CTSH is linked to neurodegenerative disease.