STAT3, a known protein for MS, is important for myelin repair, and pharmacological blockade of STAT3 activation with JAK2 inhibitors inhibits survival and differentiation of oligodendrocyte precursor cells.134 Another known protein for MS, TNFRSF1A, is involved in the TNF receptor-associated periodic syndrome, which is characterized by inflammatory demyelination. The gene discussed is JAK2; the disease is myeloid sarcoma.