These proteins are TMEM106B, SIRPA, PRSS8, GRN, CTSH, CR1, CD33, CD2AP and BLNK for AD; HIP1R for PD; TPP1, MFAP2 and TNFSF13 for ALS; and STAT3, PVR, FCRL3, CR1 and ASF1A for MS (Fig. 5). This evidence concerns the gene TMEM106B and Alzheimer disease.