BCKDK and Alzheimer disease: Twenty-three of these 50 protein–disease pairs (48%) represent previously unreported genetic associations, because they did not reach genome-wide significance in the disease GWAS, nor have they been otherwise previously reported in the GWAS Catalog (Tables 2 and 3).28 Although PRSS8 has not been previously reported as a genetic locus involved in AD, the cis pQTL for PRSS8 is a previously identified genome-wide significant association for AD, which is located within a different nearby gene (BCKDK) related to AD.9