Using a random-effects inverse-variance weighted model, we found that genetically predicted risk for AD was associated with plasma protein abundance of APOE and CEACAM19, genetically predicted risk for ALS was associated with DTX3, and genetically predicted risk for MS was associated with plasma protein abundance of CD58, JUND, CD200, PGLYRP1, TNFRSF1A, LMAN2, INHBC, DKKL1, AHSG and KLRB1 (5% FDR; Supplementary Table 4). The gene discussed is APOE; the disease is amyotrophic lateral sclerosis.