PVALB is specifically expressed by GABAergic interneurons and has been suggested as a potential MS-specific marker of grey matter neurodegeneration.146 TST is an enzyme involved in mitochondrial sulphur and selenium metabolism,147 and it has been shown that exposure to oxidative stress owing to mitochondrial dysfunction contributes to the chronic demyelination.148 ASF1A is a histone chaperone that has been implicated in neuro-inflammation and neurodegeneration processes through activation of microglia.149,150. The gene discussed is PVALB; the disease is myeloid sarcoma.