Furthermore, the risk scores of neuropsychiatric disease-associated genes increased significantly with age in the postnatal TS hippocampus, particularly for AD, ADHD, ANO, SCZ, MDD, ASD, BIP, OCD, and TOS, indicating heightened disease susceptibility in the hippocampus with aging (supplementary fig. The gene discussed is HSPA5; the disease is attention deficit-hyperactivity disorder.