CIRBP and brain injury: Clinically, therapeutic hypothermia (32°C ~ 34°C) is a means to alleviate the neurological deficits in children with hypoxic-ischemic encephalopathy and adult acute brain injury, and the synthesis of cirbp protein reaches its peak at mild to moderate hypothermia (32°C ~ 34°C), so cirbp plays a crucial role in it [10].