In VLDL-C fraction, we noticed significant decreases in So, So1P, and Cer concentrations in AF-patients before cryoablation than in the healthy volunteers (So: −19.5%; So1P: −48.7%; Cer: −43.1%; p < 0.05; Fig 3A–3C). Here, CBLN1 is linked to atrial fibrillation.