Our results showed that cryoballoon ablation in AF patients markedly reduced the level of almost all Apo compared to the individuals from the control and Pre-CBA groups (Apo-A1: −25.9% and −20.0%, Apo-A2: −19.9% and −17.3%, Apo-B: −26.8% and −14.4%, Apo-C1: −20.3% and −13.4%, Apo-D: −15.9% and −22.2%, Apo-E: −18.3% and −14.3%, and Apo-J: −36.4% and −21.5%, p < 0.05, respectively). The gene discussed is APOE; the disease is atrial fibrillation.