LPL and hypertriglyceridemia: Moreover, the group of C apolipoproteins (Apo-C1 and Apo-C3) is involved in the regulation of hepatic uptake of triglyceride-rich lipoproteins (TRL; chylomicrons and VLDL-C) by inhibiting the activity of lipoprotein lipase (LPL), which may result in hypertriglyceridemia [12].