CAMKK2 and neoplasm: We have shown that CaMKK2 expressed in macrophages regulates the immunosuppressive TME, inhibiting the tumor growth, and stimulating the anti‐tumor immune response.[89] In the current study, we identify CaMKK2 as an important target to modulate the detrimental effects of ECM stiffness on TAM, and possibly other myeloid cell types playing an important role in TME.