CaMKK2 links calcium signaling with the downstream activation of AMP‐activated protein kinase (AMPK),[63, 64] a master metabolic regulator, regulating macrophage polarization,[65, 66, 67, 68] and mechanosensory signaling.[50] Further, AKT (also known as protein kinase B) has been identified as a downstream target of CaMKK2 in tumor cells.[69] We first tested the effects of stiffness and Camkk2 deletion on Ampk phosphorylation. Here, CAMKK2 is linked to neoplasm.