AKT1 and cancer: We next investigate the effects of CaMKK2 deletion on AKT signaling, which has been reported to modulate macrophage polarization.[70, 71] The activation of AKT by CaMKK2 has been documented in cancer cells.[69, 72] In addition, we originally found a decreased accumulation of phosphorylated Akt in lipopolysaccharides (LPS)‐stimulated Camkk2−/− BMDM compared to WT.[30] Western blot analyses further showed that stiffer matrix stimulated Akt phosphorylation in WT BMDMs (Figure 7A), with 3 times increase in p‐Akt/Akt ratio (Figure 7B).