AKT regulates critical function in tumor cells and for this reason, this protein is emerging as a clinically relevant target in cancer therapy.[73] Alongside the direct effect on tumor cells, blocking of AKT stimulates T cell functions, promoting the expansion of tumor‐specific lymphocytes.[74] Our data indicates that CaMKK2 is required to couple the mechanosensory signaling with AKT activation in macrophages. The gene discussed is CAMKK2; the disease is cancer.