In addition to these chemokines, we also demonstrated the expression of Cxcl10, a critical inflammatory gene, was downregulated in stiffer environments (Figure 3); and the lack of Camkk2 counteracts the inhibitory effect of stiffness on Cxcl10, thereby impairing the ability of BMDM in the stiff matrix to sustain the tumor growth. This evidence concerns the gene CAMKK2 and neoplasm.