CXCL10 and neoplasm: In addition to these chemokines, we also demonstrated the expression of Cxcl10, a critical inflammatory gene, was downregulated in stiffer environments (Figure 3); and the lack of Camkk2 counteracts the inhibitory effect of stiffness on Cxcl10, thereby impairing the ability of BMDM in the stiff matrix to sustain the tumor growth.