ACHE and Parkinson disease: Many of the medications in typical hospice comfort kits, such as neuroleptics37,38,39 and antiemetics, can acutely worsen parkinsonism or even lead to untimely death.39 People with PD are also at high risk of inappropriate deprescribing of dopaminergic medications, which may be seen as disease-directed but in fact are essential for pain and mood management, and acetylcholinesterase inhibitors, which can markedly help with psychiatric and behavioral symptoms.