This study aimed to explore the role of safranal in a cationic bovine serum albumin (C-BSA)-induced rat model of membranous glomerulonephritis (MGN).<h4>Methods</h4>After model establishment, Sprague-Dawley rats were administered 100 or 200 mg/kg safranal by gavage. The gene discussed is ALB; the disease is membranous glomerulonephritis.