AKT1 and neoplasm: The findings that abemaciclib enhanced tumor cell radiosensitivity, enhanced phosphorylation of gamma-H2AX in combination with radiation, and reduced phosphorylation of p-AKT and p-S6 attenuating PI3K/mTOR signaling as well as alleviating radiation-induced vasculogenesis qualifies it to be a multi-functional radiation modifier.