(C) Ki67 immuno-stained sections with overlaid detection of positive (red) and negative (blue) cells; and high magnification to highlight annotations of tumor and peritumor border (P-Margin, yellow lines), in CT2A and GL261 tumors (subjects C1 and G3, respectively); and GBM cohort differences in tumor/P-Margin ratios of cell density and cell proliferation from GL261 (n=5) and CT2A (n=5) cohorts. The gene discussed is MKI67; the disease is glioblastoma.