Consequently, K63‐linked ubiquitin chains can act as non‐proteolytic signals involved in processes such as glucose uptake [39] and mitophagy [41].This finding suggests that increased DUB activity in T2D skeletal muscle may remove K63‐linked chains, impairing both insulin signalling and mitochondrial quality control. This evidence concerns the gene ZUP1 and type 2 diabetes mellitus.