In the following studies, we examined if the microgliosis induced by BI leads to microglia activation evidenced as pro‐inflammatory cytokine and chemokine release; the release of inflammatory cytokines can lead to neuronal damage including motor neuron loss as shown in pathologic state of encephalitis, ALS and other motor neuron diseases [18, 19, 20, 21, 22]. This evidence concerns the gene CACNA1A and amyotrophic lateral sclerosis.