Through cyclin-dependent kinase 6 (CDK6) and transcription factor EB (TFEB), (CDK6-TFEB) signaling, hyperin at 80 mg/kg BW has shown to resist obesity by stimulating the uncoupling protein 1 (UCP1)-dependent transition of white to beige fat, aiding in lipophagy, a particular form of autophagy that helps in breaking down lipid droplets, and enhancing lipolysis [197]. The gene discussed is CDK6; the disease is obesity due to melanocortin 4 receptor deficiency.