Additionally, the expression of CCL2, CXCL1, CXCL5, and NE correlates with EDSS scores (17), further supporting the pivotal role of ELANE in MS pathogenesis.Therapeutically, sivelestat—a selective NE inhibitor approved for the treatment of acute respiratory distress syndrome—has demonstrated potential in alleviating neuropathic pain by limiting T-cell infiltration (67). Here, ELANE is linked to myeloid sarcoma.