PYGO2 and colon adenocarcinoma: Pygopus family PHD finger 2(PYGO2), a crucial co-activator of the Wnt/β-catenin transcriptional complex (9), has been detected in multiple tumors, including colon adenocarcinoma (COAD) (10), epithelial ovarian (11), renal cell carcinoma (12), and breast (13) cancers.