CCND1 and metastatic malignant neoplasm in the lymph nodes: We observed cyclin D1 overexpression in 38% of our patients with a statistically significant correlation between a lower incidence of lymph node metastasis and cyclin D1 expression (P=0.011), which was in concordance with studies by Guo et al. and Kucukzeybeket et al. (29,30).