NOTCH1 and cancer: Lastly, the TSA-treated cells H1688 have regained Notch1 activities, which was denoted by the acquisition of epithelial-like tumor morphology after xenotransplantation as well as the “positive” change in biological properties: an increase in E-cadherin (E-Cad) epithelial markers for cell-cell adhesion, cleaved caspase 3 (CCsp3), and a decrease in both vimentin (Vim) and snail (mesenchymal transition markers), and phospho-histone H3 (P-H3), which are in favor of cancer suppression (46).