In addition, such restoration of Notch1 expression and the appearance of epithelial-like morphology in some areas highlight the possible role of epigenetic mechanisms, especially histone acetylation, in the histogenesis of combined SCLC (cSCLC), in which both SCLC and NSCLC components co-exist in same cancer (46). The gene discussed is NOTCH1; the disease is small cell lung carcinoma.