,77,78 Similarly, a study from Moslehi et al., demonstrated that the HIF pathway plays a critical role in the development of cardiomyopathy, particularly under conditions of long-term inactivation of PHD2 in cardiomyocytes, subsequently leading to long-term stabilization of EPAS1 in these cells.79 The gene discussed is EGLN1; the disease is cardiomyopathy.