Studies have shown that the nanomaterial NanoMnSor, composed of a manganese dioxide (MnO2) core and a lipid-poly (lactic-co-glycolic acid) (PLGA) shell loaded with Sorafenib, can not only promote macrophage polarization to the M1 phenotype but also reduce VEGF concentration by generating a large amount of oxygen, thereby decreasing tumor vascularization (Ding et al., 2021). The gene discussed is VEGFA; the disease is neoplasm.