Research has demonstrated that activation of the mTOR pathway increases the expression of HIF-1α and c-Myc, further upregulating glucose transporter 1 (GLUT1), glycolysis-related enzymes, LDHA, MCT1, and MCT4, thereby promoting lactate production in tumor cells (Mossmann et al., 2018) (Figure 1). The gene discussed is HIF1A; the disease is neoplasm.