Sphingosine-1-phosphate (S1P) is a bioactive lipid that binds to S1P receptor subtypes (S1PR1-5) to mediate cellular activities of the immune, cardiovascular and nervous systems.51 S1PR2 is an emerging drug target in multiple sclerosis52, which was the primary indication used for fingolimod in the MR, due to its implication in CNS demyelination. This evidence concerns the gene S1PR1 and miotic rate.