Of 57 drugs, 11 were local anesthetics (mapped to SCN2A) and 33 are listed in either the LiverTox38 or FDA DILI database39, of which five are flagged as class A (well-known cause of clinically apparent liver injury), three as class B (likely rare cause of clinically apparent liver injury), and 10 as class C (probable cause of clinically apparent liver injury) in NIH NIDDK LiverTox Database, whereas FDA classified eight of the 57 drugs as having most concern for drug-induced liver injury with confirmed causal evidence linking a drug to liver injury. The gene discussed is SCN2A; the disease is injury.