NEDD4L and chronic kidney disease: Hub genes include BCL6, PIM1, HIF1A, VEGFA, IL23A, IL6, LCN2, NEDD4L, SCNN1A, SCNN1B. Clinical data in Nephroseq V5 also showed that most hub genes upregulated in chronic kidney disease, like BCL6 (except the VEGFA, NEDD4L, SCNN1B), and negatively correlated with GFR (Figure 2C).