FOXO3 and kidney disorder: Among them, sphingolipid level is critical for maintaining renal function, abnormal expression of it may cause kidney disease (Mallela et al., 2022), and the suppressed AMPK also paly role in kidney injury through its function on renal tubular epithelial ion transport, while the FoxO signaling pathway may induce continuous autophagy in chronically hypoxic kidney through activation of Atg protein by accumulation of FoxO3 (Rajani et al., 2017).