OTUD6B and hydronephrosis: We also explored the function of chromatin structure in mediating transcriptional regulation during hydronephrosis, and found an interaction between Ureteral specific open chromatin regions and promoter of OTUD6B gene, which is a kidney disease related gene (Zhao G. et al., 2022; Guo et al., 2022) and highly expressed in disease tissue compared to normal tissue.