PI3K-Akt involves in lipotoxicity, will regulate nephrin, once decreased will lead to loss of nephrin then effect the apoptosis of podocytes, which observed in adult kidney disease, for example, diabetic nephropathy and HIV-associated nephropathy (Kato et al., 2006), (Ayasolla et al., 2015). Here, AKT1 is linked to diabetic kidney disease.