PI4K2B and COVID-19: In the pituitary, it projects to the PI4K2B gene, whose encoded protein is involved in early T cell activation; in the thyroid, it projects to SLC34A2, which codes for a protein that regulates transmembrane protein transport; and in the cerebellum, it projects to ZCCHC4. COVID-19 can directly or indirectly affect the thyroid, leading to thyroid-related diseases, possibly secondary to the hypothalamic-pituitary-thyroid (HPT) axis, which may be related to the virus’s impact on the immune system (Lui et al., 2024).