FOXO3 and chronic obstructive pulmonary disease: Moreover, studies have shown that FoxO3−/− mice displayed signs of premature aging of the enteric nervous system (48), and FOXO3Adownregulation was also reported in other inflammatory diseases, such as ankylosing spondylitis (43), chronic obstructive pulmonary disease (COPD), and ulcerative colitis (UC) (49).