DNMT3A and rheumatic disorder: The development of rheumatic disease was associated with a lower level of DNMT3A in the frailty patients group (p=0.002) (Supplementary Figure S5).Furthermore, in this group, a correlation between appendicular skeletal muscle mass (ASMM) and the expression of ELAVL1 (r=0.59, p=0.026) was observed.