For instance, M2-type macrophages can facilitate colorectal liver metastasis (CRLM) by secreting CXCL13, which subsequently activates the CXCL13/CXCR5/NF-κB/p65/miR-934 pathway in colorectal cancer (CRC) cells (111). This evidence concerns the gene NFKB1 and colorectal carcinoma.