All these findings above suggested the pivotal role of the DNA methylation of GCNT2 in immune regulation pathway in AML, and hypomethylation of TSS-A was involved in various processes of immune response, including antigen processing, presentation, recognition, and peptide antigen binding, cytokines/chemokines production, T cell activation, IFN-γ and INF-α signaling, etc. Here, IFNG is linked to acute myeloid leukemia.