GCNT2 and colorectal carcinoma: (32) have shown that methylation of variant 2 (isoform B) was critical for GCNT2 expression, and demethylation of variant 2 by 5 Aza-dC treatment could induce expression of all the three variants (or isoform A, B, and C) in CRC cell lines (32); hypomethylation of GCNT2 variant 2 was deemed to be the aggressive phenotype, significantly predicting dismal prognosis (32).