In AML, the two unique subtypes: FAB-M2 with t (8:21) generating RUNX1-RUNX1T1 fusion gene, and APL or M3 with t (15;17), generating PML-RARA fusion gene, were demonstrated to interact with DNMT3A, leading to aberrant DNA methylation that contributed to leukemogenesis (50–52). This evidence concerns the gene RARA and acute myeloid leukemia.