Herein, we have demonstrated that the transcripts of isoform B and C predominantly represented the expression of GCNT2 (r = 0.95 and r = 0.87, respectively) in AML, however, it was methylation of isoform A, rather than isoform B, substantially correlated with the transcriptional level of isoform A, B, and C (r = -0.46, P = 3.1e-10 and r = -0.44, P = 2.6e-9, respectively), as well as the GCNT2 in gene level (r = -0.48, P = 2.9e-11). The gene discussed is GCNT2; the disease is acute myeloid leukemia.