Upregulation of GCNT2 was associated with poor prognosis in breast cancer, prostate cancer, and esophageal carcinoma, with the functions of promoting proliferation, migration, and invasion, acting as an oncogene (23, 24, 26), on the other hand, evidence from other studies supposed the tumor suppressive function of GCNT2 in melanoma (25), endometrial carcinoma (29), and adult T-cell lymphoma/leukemia (28). This evidence concerns the gene GCNT2 and carcinoma of esophagus.