In addition to genetic alteration, epigenetic regulation, DNA methylation in particular, also contributes to GCNT2 expression (31, 32), data from existing observations have supported a key role of aberrant methylation of GCNT2 in several solid tumors, in which, hypomethylation of GCNT2 was associated with tumor development, invasion, and distant metastasis (32–34), interestingly, hypomethylation of GCNT2, both in tumor tissues and even in the corresponding normal tissues, holds a promising capability in predicting lymph node metastasis and clinical outcome in colorectal cancer (CRC) (32). This evidence concerns the gene GCNT2 and colorectal cancer.