Saikali et al, showed that oligodendrocytes from pwMS express ligands for the activating NK cell receptor NKG2D that were not detected in healthy control samples, and that blocking NKG2D on NK cells significantly inhibited the killing of oligodendrocytes, suggesting a NKG2D-mediated killing mechanism for tissue injury in MS (173). This evidence concerns the gene KLRK1 and myeloid sarcoma.