These neurons showed upregulation of the X-linked genes TSC22D3, HMGB3, and SYP. Additionally, a similar phenotype was observed in AD iPSC-derived neural progenitor cells, which demonstrated significantly impaired expression of several X-linked genes, including DDX3X, TLR7, TLR8, BTK, ACE2, WAS, CYBB, CFP, and IL13RA. Overexpression was identified solely for the IL1RAPL1 gene, which is implicated in dendrite differentiation (58) and SYP gene which has been shown to be responsible for intellectual disability (59). The gene discussed is SYP; the disease is Intellectual disability.