Alternatively, endothelial dysfunction may contribute to the development of cerebral amyloidosis and Alzheimer's disease in APOE4 carriers vulnerable to vascular amyloid clearance and blood-brain barrier disruption [8,[36], [37], [38], [39], [40], [41], [42], [43], [44], [45]]. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.