Secondary: Changes in fasting plasma glucose, total insulin dose, HbA1c, body weight, waist circumference, neck circumference, blood pressure, resting pulse rate, 6-minute walking distance, body fat percentage, serum cholesterol levels, highly sensitive CRP, interleukin 6, leptin levels, and 10-year risk of coronary heart disease. The gene discussed is IL6; the disease is coronary artery disorder.