INS and type 2 diabetes mellitus: Age: Participants aged 35–65 years; Diagnosis: Participants with T2DM diagnosed at least 4 years previously; BMI: Participants with a BMI of ≥35 kg/m2; Weight: Participants with a body weight of less than 185 kg.; Insulin Therapy: Participants who had been on insulin treatment for at least 12 months; HbA1c: Participants with HbA1c levels of ≥6.5%.