For instance, exosomes derived from M1 macrophages inhibit the expression of human methyltransferase-like 14 (METTL14) in hepatocellular carcinoma (HCC) cells by transferring miR-628-5p, while METTL14 promotes m6A modification of circFUT8, facilitating its cytoplasmic export (54). Here, METTL14 is linked to hepatocellular carcinoma.