ARG1 and neoplasm: For instance, studies have found that exosome-enriched circNEIL3 can be secreted by glioblastoma cells into tumor-associated macrophages (TAMs), stabilizing the expression of IGF2BP3 and upregulating pro-inflammatory factors like IL-10 and ARG1, inducing M2 immune suppressive polarization, and ultimately leading to tumor immune evasion (83).