For example, circRNA-6834 suppresses NSCLC progression by destabilizing ANHAK and regulating the miR-873-5p/TXNIP axis (37); CircHERC1 promotes NSCLC cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis (38). The gene discussed is HMGB1; the disease is non-small cell lung carcinoma.