NRG1 and familial pancreatic carcinoma: For instance, circDENND4C upregulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating the Wnt/β-catenin signal pathway (45); miR-200b suppresses gastric cancer cell migration and invasion by inhibiting NRG1 through ERBB2/ERBB3 signaling (46); the co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer (47).