These findings tie well with the previous studies wherein to study the interaction between amyloid-β (Aβ) and tau and their effect on synaptic function, the 3xTg-AD mouse model that contains three genetic mutations associated with familial AD (APP Swedish, MAPT P301L, and PSEN1 M146V), when given a selective α1-AR positive allosteric modulator, spatial memory was improved along with LTP. Here, MAPT is linked to Alzheimer disease.