Similarly, Saccharomyces and Aspergillus were found in higher concentrations in MS patients; the former was positively correlated with circulating basophils but negatively correlated with regulatory B cells, while the latter was positively correlated with activated CD16+ dendritic cells.120 Additionally, there appeared to be fewer butyrate products in the gut microbiota of MS patients.121 Butyrate can upregulate Treg populations via G-protein-coupled receptors for short-chain fatty acids (SCFAs) and enhance the synthesis of anti-inflammatory cytokines, including IL-10 and IL-4. The gene discussed is IL10; the disease is myeloid sarcoma.