Aberrant phosphorylation of CDC25C-T48 was identified in FLT3-ITD-mutated cells and CDC25C was demonstrated to be a downstream target of the mutated FLT3-ITD tyrosine kinase, affecting cell-cycle regulation in AML (55), and highlighting the role of this phosphatase in regulating the G2/M transition and promoting cell cycle progression. Here, CDC25C is linked to acute myeloid leukemia.