,23 The latter is increasingly used as a second-line NIT for staging liver fibrosis and comprises HA (hyaluronic acid),24 PIIINP (procollagen III amino-terminal peptide),25 and TIMP-1 (tissue inhibitor of metalloproteinase 1),26i.e. three biomarkers of extracellular matrix remodelling that have also been individually linked to PH. Here, TIMP1 is linked to Hepatic fibrosis.