Despite that prior studies have investigated the role of WNT11 and Wnt signaling in both in vivo and in vitro models of pulmonary fibrosis (Henderson et al., 2010; Liu et al., 2021), the direct molecular targets or downstream signaling of WNT11 and the mechanism by which WNT11 interacts with other profibrotic molecules to regulate the pathogenesis of pulmonary fibrosis still remain unclear. The gene discussed is WNT11; the disease is pulmonary fibrosis.