COL27A1 and pulmonary fibrosis: As the Collagen-I plays a crucial role in fibrogenesis (Yang et al., 2013) and the pulmonary fibrosis is characterized by its accumulation (Ding et al., 2021), the reduction in Collagen-I deposition caused by knocking out the COL20A1, COL27A1, and WNT11 may indicate a potential direction for pulmonary fibrosis treatment.