Although a polygenic disease, common genetic variants have been consistently associated with increased risk of steatosis, particularly small nucleotide polymorphisms (SNPs) in Patatin-like phospholipase domain-containing protein 3 (PNPLA3), Lysophospholipase-like 1 (LYPLAL1), protein phosphatase 1 regulatory subunit 3B (PPP1R3B), Neurocan (NCAN) and glucokinase regulator (GCKR) [[14], [15], [16]]. The gene discussed is LYPLAL1; the disease is steatosis.