The depletion of Rab46 in endothelial cells could therefore lead to the increased inflammation necessary for NAFLD disease progression, especially since SNPs in EFCAB4B [25] and the presence of NAFLD [26] have been associated with extreme inflammatory responses to COVID-19, with significantly increased serum levels of Weibel-Palade body cargo such as von Willebrand factor and Angiopoietin 2 [27]. The gene discussed is VWF; the disease is metabolic dysfunction-associated steatotic liver disease.