For example, expression of inhibitor of DNA binding1 (ID1), phosphomevalonate kinase (PMVK), G protein-coupled receptor 146 (GPR146) [40] and X-box binding protein-1 (XBP1) are upregulated and phosphoenolpyruvate carboxykinase 1 (PCK1) downregulated in NAFLD or lipid disorders, this is reflected in the livers of Efcab4b−/− mice as compared to WT. The gene discussed is GPR146; the disease is metabolic dysfunction-associated steatotic liver disease.