The differential diagnosis of DSRCT can be with a variety of other round-cell tumors, including Ewing sarcoma, rhabdomyosarcoma, small-cell carcinoma, and mesothelioma.21,22) In most cases of DSRCT, the expression of Desmin, Cytokeratin (CK), Epithelial membrane antigen (EMA), and vimentin is positive. Here, DES is linked to small cell carcinoma.