The differential diagnosis of DSRCT can be with a variety of other round-cell tumors, including Ewing sarcoma, rhabdomyosarcoma, small-cell carcinoma, and mesothelioma.21,22) In most cases of DSRCT, the expression of Desmin, Cytokeratin (CK), Epithelial membrane antigen (EMA), and vimentin is positive. The gene discussed is MUC1; the disease is desmoplastic small round cell tumor.