The WRKY22 transcription factor reached its highest expression level on the 4th day and 5th day of pathogen infection, while the gene in the VIP1 promoter continued to be upregulated during the pathogen infection period, reaching its highest level on the 5th day of inoculation, further activating PR1 for defense response against the late stage of pathogen infection. The gene discussed is TMEM37; the disease is infection.