HFE and Tangier disease: Type 1 hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with incomplete penetrance associated with variation in the HFE (homeostatic iron regulator, HGNC:4886, GRCh38 reference) gene and characterized by iron overload due to excessive absorption of dietary iron.1, 2, 3 Iron overload can lead to increased iron deposition in organs, resulting in cirrhosis, liver cancer, and increased mortality.4