CUL1 and melanoma: In Figure 4 we consider the low confidence regions of AF2 structures of the preferentially expressed antigen in melanoma (PRAME) family member 20, replacing the low confidence region residue 116–145; we also consider Cullin-1 with two IDR regions: an N-terminal IDR 1–15 and a linker IDR between 56–82.59 We find that IDPForge conformers sample a much broader distance range than the initial AF2 models as seen in Fig. 4 and exhibit a greater range of secondary structure types compared to the primarily featureless coil structures from AF2.