circ_HEATR5B encodes a new protein HEATR5B-881aa, which directly interacts with Jumonji C-domain containing 5 (JMJD5) and reduces the stability of JMJD5 by phosphorylating S361, thereby inhibiting glycolysis and proliferation in GBM cells.40 This evidence concerns the gene KDM8 and glioblastoma.