CORO1C-47aa competes with the transcription factor TACC3 (transforming acidic coiled-coil containing protein 3) for binding to ARNT (aryl hydrocarbon receptor nuclear translocator) via the PAS-B structural domain, resulting in transcriptional inhibition of VEGF (vascular endothelial growth factor) and ultimately reducing endometrial cancer angiogenesis. The gene discussed is VEGFA; the disease is endometrial cancer.