The 235aa polypeptide encoded by circ_8199 is mainly located in the cytoplasm, and can inhibit esophageal squamous-cell carcinoma cell proliferation by binding to and inhibiting the activity of OGT (O-linked N-acetylglucosamine transferase) through the JAK2 (Janus kinase 2)-STAT3 pathway.60 The gene discussed is JAK2; the disease is esophageal squamous cell carcinoma.