This novel β-catenin isoform promotes hepatocellular carcinoma (HCC) proliferation and metastasis by antagonizing GSK3β (glycogen synthase kinase 3 beta)-induced β-catenin phosphorylation and degradation, stabilizing full-length β-catenin, and activating the Wnt pathway. This evidence concerns the gene GSK3B and hepatocellular carcinoma.