Exosome circATG4B was found to encode a new protein CircatG4B-222AA in CRC, and CircatG4B-222AA interacts with TMED10, preventing TMED10 from binding to ATG4B, thereby leading to increased autophagy and inducing oxaliplatin resistance in CRC cells.55 The gene discussed is ATG4B; the disease is colorectal carcinoma.