SOX2 gene amplification has emerged as a potent driver in various malignancies, including lung cancer, gastric cancer, colorectal cancer, and esophageal cancer.79, 80, 81, 82 In a distinct study, the spotlight turned to the E3 Ub ligase UBR5, which displayed a nuanced interaction with SOX2 in esophageal cancer cells. This evidence concerns the gene SOX2 and esophageal cancer.