Among proteins that are upregulated with cold and downregulatedwith heat, LRP1 plays an important role in lipid homeostasis and actsas a master regulator of tau uptake and spread,62 which have significant implications on obesity and riskof CVD and dementia; CD69, CCL2, and MMP7 may play a role in immuneresponses involving memory T cells63,64 and alveolarepithelial injuries,65 which are consistentwith the higher risks of infection with cold temperature. The gene discussed is CD69; the disease is Obesity.