IL22 and cardiovascular disorder: The DEPs include well-establishedchemokines (e.g., CCL2, CXCL5, CXCL3, and PPBP), enzymes (e.g., MMP1and MMP7), and interleukins (e.g., IL22 and IL15) involved in inflammation-,immunity-, and infection related pathways with etiological relevanceto a wide range of diseases beyond cardiovascular disease.41−43 Key DEPs such as MPIG6B44 and MGLL45 were involved in hemostasis and platelet activation,signaling, aggregation, and degranulation, suggesting a potentialrole of temperatures in hemorrhage or thrombosis and ischemic vascularissues.