For IHD, while we have previouslyshown higher levels of 13 proteins to be causally and positively associatedwith increased risk,31 four (CCL17, TFPI,F2R, ASGR1) of them were also found to be upregulated with cold, whichare consistent with the widely reported winter surge in cardiovascularmortality and hospitalization related to low temperature.40 The gene discussed is F2R; the disease is myocardial ischemia.