As the five ADRD risk indexes capture global ADRD risk across domains as diverse as genetic risk (e.g., APOE ε4 status), lifestyle risk (e.g., alcohol consumption, physical activity), cardiometabolic risk (e.g., hypertension, diabetes status), and harmful events (e.g., traumatic brain injuries), the primary analyses may overlook underlying nuanced patterns in the association of retinal health with midlife ADRD risk. This evidence concerns the gene APOE and Hypertension.