Interestingly, however, CRVE was associated with additional risk domains less likely to be purely resulting from cardiovascular risk: socioeconomic status (occupational and educational attainment); psychological and somatic function (pain interference, migraine, depression, loneliness/social isolation, sleep quality, and neuroticism & conscientiousness); and inflammatory risk (levels of CRP, IL-6, and suPAR, and rheumatoid arthritis). Here, CRP is linked to major depressive disorder.