To determine the role of mouse MGL1 in colitis‐associated colon cancer (CAC), azoxymethane (AOM)/dextran sodium sulfate (DSS)‐induced tumor development was compared between Mgl1 knockout (Mgl1−/−) mice and their wild‐type (WT) littermates. This evidence concerns the gene LLGL1 and malignant colon neoplasm.