In children 5–14 years of age at enrolment, increasing antibody levels to specific P. falciparum antigens were associated with an increased risk of developing clinical malaria (Fig. 4), including IgG3 to LSA-1 and GLURP-R0 (1.78 [1.11, 2.86] and 2.30 [1.02, 5.15], respectively), and IgA to CSP, GLURP-R0, MSP-2 and MSP-3 (1.77 [1.00, 3.12], 2.17 [1.04, 4.49], 1.76 [1.03, 3.00], and 5.54 [1.72, 17.84], respectively). This evidence concerns the gene CD79A and malaria.