These included antibodies previously associated with protection against clinical malaria in young children in areas of high transmission, including IgG antibodies to CSP [12], AMA-1 [20] and MSP-2 [20], IgG1 antibodies to EBA-175[53], IgG3 antibodies to CSP [21] and MSP-2 [15], and IgM antibodies to EBA-175 [16]. The gene discussed is IGHG3; the disease is malaria.