IGHG3 and malaria: In children 5–14 years of age at enrolment, increasing antibody levels to specific P. falciparum antigens were associated with an increased risk of developing clinical malaria (Fig. 4), including IgG3 to LSA-1 and GLURP-R0 (1.78 [1.11, 2.86] and 2.30 [1.02, 5.15], respectively), and IgA to CSP, GLURP-R0, MSP-2 and MSP-3 (1.77 [1.00, 3.12], 2.17 [1.04, 4.49], 1.76 [1.03, 3.00], and 5.54 [1.72, 17.84], respectively).