However, in individuals ≥ 15 years of age, the combination of all significant IgG and IgG1 antibody levels showed only a modest increase in predictive value of risk of clinical malaria than single-antigen antibody levels (e.g., AUROC 0.68 for IgG1 to CSP + AMA1 + EBA-175 RIII vs. 0.64 for CSP, Table S5). Here, DNAJC5 is linked to malaria.