NFATC1 and breast cancer: Furthermore, PAF plays a crucial role in promoting bone metastases in BC and inducing the differentiation of bone marrow monocytes (BMMs) through inhibiting nuclear factor kappa-B (NF-κB) activation, and the differentiation of osteoclast via blocking nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1 transcription activity [114].